Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study.

Autor:	Di Mascio D; Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy., Khalil A; Fetal Medicine Unit, Saint George's Hospital, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, United Kingdom., Pilu G; Unit of Obstetrics, Department of Medical and Surgical Sciences, University of Bologna, Italy., Rizzo G; Division of Maternal and Fetal Medicine, Ospedale Cristo Re, University of Rome Tor Vergata, Rome, Italy; Department of Obstetrics and Gynecology The First I.M. Sechenov Moscow State Medical University, Moscow, Russia., Caulo M; Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, 'G. D'Annunzio' University of Chieti, Italy., Liberati M; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy., Giancotti A; Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy., Lees C; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, United Kingdom; Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom., Volpe P; Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy., Buca D; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy., Oronzi L; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy., D'Amico A; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy., Tinari S; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy., Stampalija T; Unit of Fetal Medicine and Prenatal Diagnosis, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Fantasia I; Unit of Fetal Medicine and Prenatal Diagnosis, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Pasquini L; Fetal Medicine Unit, Department for Women and Children Health, AOU Careggi, Florence, Italy., Masini G; Fetal Medicine Unit, Department for Women and Children Health, AOU Careggi, Florence, Italy., Brunelli R; Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy., D'Ambrosio V; Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy., Muzii L; Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy., Manganaro L; Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Italy., Antonelli A; Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Italy., Ercolani G; Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Italy., Ciulla S; Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Italy., Saccone G; Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, Federico II University of Naples, Italy., Maruotti GM; Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, Federico II University of Naples, Italy., Carbone L; Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, Federico II University of Naples, Italy., Zullo F; Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, Federico II University of Naples, Italy., Olivieri C; Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy., Ghi T; Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Italy., Frusca T; Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Italy., Dall'Asta A; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, United Kingdom; Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Italy., Visentin S; Department of Woman' and Child's Health, University of Padova, Padova, Italy., Cosmi E; Department of Woman' and Child's Health, University of Padova, Padova, Italy., Forlani F; Department of Obstetrics and Gynaecology, Arnas Civico Hospital, Palermo, Italy., Galindo A; Fetal Medicine Unit, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, Complutense University of Madrid, Department of Obstetrics and Gynaecology, Madrid, Spain., Villalain C; Fetal Medicine Unit, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, Complutense University of Madrid, Department of Obstetrics and Gynaecology, Madrid, Spain., Herraiz I; Fetal Medicine Unit, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, Complutense University of Madrid, Department of Obstetrics and Gynaecology, Madrid, Spain., Sileo FG; Fetal Medicine Unit, Saint George's Hospital, London, United Kingdom; Department of Biochemical, Metabolic and Neural Sciences, International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy; Unit of Obstetrics and Gynecology, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy., Mendez Quintero O; Fetal Medicine Unit, Saint George's Hospital, London, United Kingdom., Salsi G; Unit of Obstetrics, Department of Medical and Surgical Sciences, University of Bologna, Italy., Bracalente G; Fetal Medicine Unit, Department of Obstetrics and Gynecology, Osp. Cà Foncello Treviso, Italy., Morales-Roselló J; Servicio de Obstetricia, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Pediatría Obstetricia y Ginecología, Universidad de Valencia, Spain., Loscalzo G; Servicio de Obstetricia, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Pediatría Obstetricia y Ginecología, Universidad de Valencia, Spain., Pellegrino M; Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., De Santis M; Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., Lanzone A; Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., Parazzini C; Pediatric Radiology and Neuroradiology Department, Children's Hospital V. Buzzi, Università di Milano, Italy., Lanna M; Fetal Therapy Unit 'Umberto Nicolini', Children's Hospital, V. Buzzi Università di Milano, Italy., Ormitti F; Department of Radiology - Azienda Ospedaliera Universitaria di Parma, Italy., Toni F; IRCCS Istituto delle Scienze Neurologiche UOC Neuroradiologia, Bologna, Italy., Murru F; Unit of Paediatric Radiology, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Italy., Di Maurizio M; UOC Radiodiagnostica, AOU Meyer, Florence, Italy., Trincia E; UOC Neuroradiologia, Osp. Cà Foncello Treviso, Italy., Garcia R; Complejo Hospitalario Universitario Insular - Materno Infantil de Canarias, Las Palmas de Gran Canaria, Spain., Bennike Bjørn Petersen O; Center for Fetal Medicine and Ultrasound, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark., Neerup L; Center for Fetal Medicine and Ultrasound, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Sandager P; Center for Fetal Medicine, Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark; Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark., Prefumo F; Division of Obstetrics and Gynecology, Department of Clinical and Experimental Sciences, University of Brescia, Italy., Pinelli L; Neuroradiology Unit, Pediatric Neuroradiology Section, ASST Spedali Civili, Brescia, Italy., Mappa I; Division of Maternal and Fetal Medicine, Ospedale Cristo Re, University of Rome Tor Vergata, Rome, Italy., Acuti Martellucci C; Department of Medical Sciences, University of Ferrara, Italy., Flacco ME; Department of Medical Sciences, University of Ferrara, Italy., Manzoli L; Department of Medical Sciences, University of Ferrara, Italy., Giangiordano I; Department of Child and Adolescent Neuropsychiatry, Local Health Unit of Avezzano-Sulmona-L'Aquila, Sulmona, Italy., Nappi L; Fetal Medicine Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy., Scambia G; Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., Berghella V; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, USA., D'Antonio F; Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy. Electronic address: francesco.dantonio@unich.it.
Jazyk:	angličtina
Zdroj:	European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2021 Dec; Vol. 267, pp. 105-110. Date of Electronic Publication: 2021 Oct 23.
DOI:	10.1016/j.ejogrb.2021.10.014
Abstrakt:	Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (≥15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonography had been performed. The primary outcome was the rate of additional CNS anomalies detected exclusively at fetal MRI within two weeks from neurosonography. Subgroup analyses according to gestational age at MRI (Results: 187 fetuses with a prenatal diagnosis of isolated severe ventriculomegaly on neurosonography were included in the analysis. Additional structural anomalies were detected exclusively at prenatal MRI in 18.1% of cases. When considering the type of anomaly, malformations of cortical development were detected on MRI in 32.4% cases, while midline or acquired (hypoxemic/hemorrhagic) lesions were detected in 26.5% and 14.7% of cases, respectively. There was no difference in the rate of additional anomalies when stratifying the analysis according to either gestational age at MRI or laterality of the lesion. At multivariate logistic regression analysis, the presence of additional anomalies only found at MRI was significantly higher in bilateral compared versus unilateral ventriculomegaly (OR: 4.37, 95% CI 1.21-15.76; p = 0.04), while neither maternal body mass index, age, severity of ventricular dilatation, interval between ultrasound and MRI, nor gestational age at MRI were associated with the likelihood of detecting associated anomalies at MRI. Conclusion: The rate of associated anomalies detected exclusively at prenatal MRI in fetuses with isolated severe ventriculomegaly is lower than previously reported, but higher compared to isolated mild and moderate ventriculomegaly. Fetal MRI should be considered as a part of the prenatal assessment of fetuses presenting with isolated severe ventriculomegaly at neurosonography. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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