Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck.

Autor: Roos JH; Department of Otolaryngology, Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. johan.roos@helsinki.fi., Mäkitie AA; Department of Otolaryngology, Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Tarkkanen J; Department of Pathology, HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Ilmarinen TT; Department of Otolaryngology, Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2022 Jun; Vol. 279 (6), pp. 3147-3155. Date of Electronic Publication: 2021 Nov 12.
DOI: 10.1007/s00405-021-07162-0
Abstrakt: Background: Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common.
Methods: This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival.
Results: The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS.
Conclusions: Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size.
(© 2021. The Author(s).)
Databáze: MEDLINE
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