Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial.
| Autor: | Hontelez S; Host-Microbe Interactomics, Wageningen University and Research, De Elst 1, 6708 WD, Wageningen, The Netherlands. ADHD@wur.nl., Stobernack T; Host-Microbe Interactomics, Wageningen University and Research, De Elst 1, 6708 WD, Wageningen, The Netherlands., Pelsser LM; ADHD Research Centre, Eindhoven, The Netherlands., van Baarlen P; Host-Microbe Interactomics, Wageningen University and Research, De Elst 1, 6708 WD, Wageningen, The Netherlands., Frankena K; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Groefsema MM; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands., Kleerebezem M; Host-Microbe Interactomics, Wageningen University and Research, De Elst 1, 6708 WD, Wageningen, The Netherlands., Rodrigues Pereira R; Medical Centre Kinderplein, Rotterdam, The Netherlands., Postma EM; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Smeets PAM; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Stopyra MA; Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany., Zwiers MP; Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Aarts E; Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Scientific reports [Sci Rep] 2021 Nov 12; Vol. 11 (1), pp. 22205. Date of Electronic Publication: 2021 Nov 12. |
| DOI: | 10.1038/s41598-021-01684-7 |
| Abstrakt: | Research into the effect of nutrition on attention-deficit hyperactivity disorder (ADHD) in children has shown that the few-foods diet (FFD) substantially decreases ADHD symptoms in 60% of children. However, the underlying mechanism is unknown. In this open-label nutritional intervention study we investigated whether behavioural changes after following an FFD are associated with changes in brain function during inhibitory control in 79 boys with ADHD, aged 8-10 years. Parents completed the ADHD Rating Scale before (t1) and after the FFD (t2). Functional magnetic resonance imaging (fMRI) scans were acquired during a stop-signal task at t1 and t2, and initial subject-level analyses were done blinded for ARS scores. Fifty (63%) participants were diet responders, showing a decrease of ADHD symptoms of at least 40%. Fifty-three children had fMRI scans of sufficient quality for further analysis. Region-of-interest analyses demonstrated that brain activation in regions implicated in the stop-signal task was not associated with ADHD symptom change. However, whole-brain analyses revealed a correlation between ADHD symptom decrease and increased precuneus activation (p (© 2021. The Author(s).) |
| Databáze: | MEDLINE |
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