| Autor: |
Van Damme J; Department of Urology, Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Tombal B; Department of Urology, Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Collette L; International Drug Development Institute (IDDI), B-1341 Louvain-la-Neuve, Belgium., Van Nieuwenhove S; Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC-IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Pasoglou V; Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC-IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Gérard T; Department of Nuclear Medicine, Institut de Recherche Expérimentale et Clinique (IREC-MIRO), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Jamar F; Department of Nuclear Medicine, Institut de Recherche Expérimentale et Clinique (IREC-MIRO), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Lhommel R; Department of Nuclear Medicine, Institut de Recherche Expérimentale et Clinique (IREC-MIRO), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium., Lecouvet FE; Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC-IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium. |
| Abstrakt: |
Background: Prostate specific membrane antigen (PSMA) positron emission tomography computed tomography (PET-CT) and whole-body magnetic resonance imaging (WB-MRI) outperform standard imaging technology for the detection of metastasis in prostate cancer (PCa). There are few direct comparisons between both modalities. This paper compares the diagnostic accuracy of PSMA PET-CT and WB-MRI for the detection of metastasis in PCa. One hundred thirty-four patients with newly diagnosed PCa ( n = 81) or biochemical recurrence after curative treatment ( n = 53) with high-risk features prospectively underwent PSMA PET-CT and WB-MRI. The diagnostic accuracy of both techniques for lymph node, skeletal and visceral metastases was compared against a best valuable comparator (BVC). Overall, no significant difference was detected between PSMA PET-CT and WB-MRI to identify metastatic patients when considering lymph nodes, skeletal and visceral metastases together (AUC = 0.96 (0.92-0.99) vs. 0.90 (0.85-0.95); p = 0.09). PSMA PET-CT, however, outperformed WB-MRI in the subgroup of patients with newly diagnosed PCa for the detection of lymph node metastases (AUC = 0.96 (0.92-0.99) vs. 0.86 (0.79-0.92); p = 0.0096). In conclusion, PSMA PET-CT outperforms WB-MRI for the detection of nodal metastases in primary staging of PCa. |
