| Autor: |
Alessio N; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Squillaro T; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Lettiero I; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Galano G; ASL Napoli 1 Centro P.S.I. Napoli Est-Barra, 80147 Naples, Italy., De Rosa R; ASL Napoli 1 Centro P.S.I. Napoli Est-Barra, 80147 Naples, Italy., Peluso G; Research Institute on Terrestrial Ecosystems, CNR, 80131 Naples, Italy., Galderisi U; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.; Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA., Di Bernardo G; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.; Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA. |
| Abstrakt: |
Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells. Against that background, we evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body's homeostasis. Among our results, piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs. Altogether, our findings demonstrate piceatannol's effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence. Our study thus suggests that, given piceatannol's various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes. |
