Coping strategies in patients with acute myeloid leukemia.

Autor:	Amonoo HL; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA.; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Bodd MH; Division of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and., Reynolds MJ; Division of Hematology and Oncology, Department of Medicine, and., Nelson AM; Harvard Medical School, Boston, MA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA., Newcomb R; Division of Hematology and Oncology, Department of Medicine, and., Johnson PC; Division of Hematology and Oncology, Department of Medicine, and., Dhawale TM; Division of Hematology and Oncology, Department of Medicine, and., Plotke R; Division of Hematology and Oncology, Department of Medicine, and., Heuer L; Division of Hematology and Oncology, Department of Medicine, and., Gillani S; Division of Hematology and Oncology, Department of Medicine, and., Yang D; Division of Hematology and Oncology, Department of Medicine, and., Deary EC; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA., Daskalakis E; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA., Goldschen L; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA., Brunner A; Harvard Medical School, Boston, MA.; Division of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and.; Division of Hematology and Oncology, Department of Medicine, and., Fathi AT; Harvard Medical School, Boston, MA.; Division of Hematology and Oncology, Department of Medicine, and., LeBlanc TW; Division of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and., El-Jawahri A; Harvard Medical School, Boston, MA.; Division of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and.; Division of Hematology and Oncology, Department of Medicine, and.
Jazyk:	angličtina
Zdroj:	Blood advances [Blood Adv] 2022 Apr 12; Vol. 6 (7), pp. 2435-2442.
DOI:	10.1182/bloodadvances.2021005845
Abstrakt:	Patients diagnosed with acute myeloid leukemia (AML) face sudden-onset life-threatening disease that requires intensive treatments. Although their early disease trajectory is characterized by significant, toxic side effects, limited data are available describing coping strategies among patients with AML and how these inform patient-reported outcomes. We used cross-sectional secondary data analyses to describe coping in 160 patients with newly diagnosed high-risk AML. The Brief COPE, Hospital Anxiety and Depression Scale, Post-Traumatic Stress Disorder Checklist-Civilian Version, and Functional Assessment of Cancer Therapy-Leukemia were used at time of AML diagnosis to measure coping strategies, psychological distress, and quality of life (QOL), respectively. The median split method for distribution of coping domains and multivariate regression models were used to assess the relationship between coping and patient-reported outcomes. Participants (median age, 64.4 years) were mostly non-Hispanic White (86.3%), male (60.0%), and married (73.8%). Most (51.9%) had high utilization of approach-oriented coping strategies, whereas 38.8% had high utilization of avoidant coping strategies. At time of diagnosis, use of approach-oriented coping was associated with less psychological distress (anxiety, β = -0.262, P = .002; depression symptoms, β = -0.311, P < .001; and posttraumatic distress disorder symptoms, β = -0.596, P = .006) and better QOL (β = 1.491, P = .003). Use of avoidant coping was associated with more psychological distress (anxiety, β = 0.884, P < .001; depression symptoms, β = 0.697, P < .001; and posttraumatic distress disorder symptoms, β = 3.048, P < .001) and worse QOL (β = -5.696, P < .001). Patients with high-risk AML use various approach-oriented and avoidant coping strategies at time of diagnosis. Use of approach-oriented coping strategies was associated with less psychological distress and better QOL, suggesting a possible target for supportive oncology interventions. (© 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
Databáze:	MEDLINE
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