Placental deficiency during maternal SARS-CoV-2 infection.

Autor: Celik E; Koc University, School of Medicine, Department of Obstetrics and Gynecology, Turkey., Vatansever C; Koc University, School of Medicine, Department of Medical Microbiology, Turkey; Koç University İşBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey., Ozcan G; Koc University, School of Medicine, Department of Medical Microbiology, Turkey; Koç University İşBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey., Kapucuoglu N; Koc University, School of Medicine, Department of Pathology, Turkey., Alatas C; American Hospital, Department of Obstetrics and Gynecology, Turkey., Besli Y; American Hospital, Department of Microbiology, Turkey., Palaoglu E; American Hospital, Department of Microbiology, Turkey., Gursoy T; Koc University, School of Medicine, Department of Pediatrics, Turkey., Manici M; Koc University, School of Medicine, Department of Anesthesiology & Reanimation, Turkey., Turgal M; Koc University, School of Medicine, Department of Obstetrics and Gynecology, Turkey., Dogan O; Koc University, School of Medicine, Department of Medical Microbiology, Turkey; Koç University İşBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey., Cekic SG; Koc University, School of Medicine, Department of Obstetrics and Gynecology, Turkey., Duru B; Acibadem International Hospital, Department of Obstetrics and Gynecology, Turkey., Ata B; Koc University, School of Medicine, Department of Obstetrics and Gynecology, Turkey., Ergonul O; Koc University, School of Medicine, Department of Clinical Microbiology, and Infectious Diseases, Turkey; Koç University İşBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey., Can F; Koc University, School of Medicine, Department of Medical Microbiology, Turkey; Koç University İşBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey. Electronic address: fucan@ku.edu.tr.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2022 Jan; Vol. 117, pp. 47-56. Date of Electronic Publication: 2021 Oct 23.
DOI: 10.1016/j.placenta.2021.10.012
Abstrakt: Introduction: Maternal anti-SARS-CoV-2 Spike antibodies can cross the placenta during pregnancy, and neonates born to infected mothers have acquired antibodies at birth. Few studies reported data on the histopathological changes of the placenta during infection and placental infection. SARS-CoV-2 infection may cause impaired development of the placenta, thus predisposing maternal and fetal unfavorable outcomes. The prospective study aims to evaluate the risk of vertical transmission of SARS-CoV-2 and placental passage of anti-Spike antibodies as well as the impact of clinical severity on placental structures.
Methods: This is a prospective cohort study on 30 pregnant women infected by SARS-CoV-2 with their neonates. The demographic features and pregnancy outcomes were collected. Gross and microscopic examinations of the placentas were done. Maternal and umbilical cord sera were obtained at the time of delivery. Nasopharyngeal swabs were collected from neonates immediately after birth.
Results: The concentrations of total anti-SARS-CoV-2 Spike antibodies were higher in pregnant women with moderate to severe/critical disease. The maternal total anti-SARS-CoV-2 Spike levels were correlated with those of neonatal levels. The rate of placental abnormalities is high in the mothers with severe disease, and those with positive anti-SARS-CoV-2 IgM. All neonates had negative nasopharyngeal swabs for SARS- CoV-2 infections and all placentas were negative in immunohistochemical staining for Spike protein.
Discussion: The maternally derived anti-SARS-CoV-2 Spike antibody can transmit to neonates born to infected mothers regardless of gestational age. Our results indicated that the disease severity is associated with ischemic placental pathology which may result in adverse pregnancy outcomes.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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