Lepidium meyenii (maca) and soy isoflavones reduce cardiac stunning of ischemia-reperfusion in rats by mitochondrial mechanisms.
| Autor: | Colareda GA; Cátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina., Matera SI; Cátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina., Bayley M; Cátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina., Ragone MI; Cátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina., Flores ML; Cátedra de Farmacognosia, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, s/N°, Comodoro Rivadavia, 9000, Chubut, Argentina., Córdoba OL; Cátedra de Química Biológica II, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, s/N°, Comodoro Rivadavia, 9000, Chubut, Argentina., Consolini AE; Cátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of traditional and complementary medicine [J Tradit Complement Med] 2021 Apr 02; Vol. 11 (6), pp. 471-480. Date of Electronic Publication: 2021 Apr 02 (Print Publication: 2021). |
| DOI: | 10.1016/j.jtcme.2021.03.004 |
| Abstrakt: | Background and Aim: Phytoestrogens are traditionally used for cardiovascular risks but direct effects on the ischemic heart remain unclear. Plants with phytoestrogens are used for reducing menopausic symptoms and they could also be cardioprotectives. Here we investigated whether maca (Lepidium meyenii ) contains isoflavones and prevents cardiac stunning, in comparison to soy isoflavones. Experimental Procedure: Both products were orally and daily administered to rats during 1 week before exposing isolated hearts to ischemia/reperfusion (I/R). Young male (YM), female (YF) and aged female (AgF) rats treated with maca (MACA, 1 g/kg/day) or soy isoflavones (ISOF, 100 mg/kg/day) were compared to acute daidzein (DAZ, 5 mg/kg i.p.) and non-treated rat groups. Isolated ventricles were perfused inside a calorimeter to simultaneously measure contractile and calorimetrical signals before and during I/R. Results and Conclusions: Maca has genistein and daidzein. MACA and ISOF improved the post-ischemic contractile recovery (PICR) and muscle economy (P/Ht) in YM and YF hearts, but not in AgF hearts. DAZ improved PICR and P/Ht more in YM than in YF. The mK Competing Interests: The authors want to declare that they have no conflict of interest associated with this publication. (© 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.) |
| Databáze: | MEDLINE |
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