Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos.

Autor:	Makwe CC; Obstetrics and Gynaecology, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Lagos, NGA., Soibi-Harry AP; Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, NGA., Rimi GS; Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, NGA., Ugwu OA; Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, NGA., Ajayi AT; Department of Radiodiagnosis, Lagos University Teaching Hospital, Lagos, NGA., Adesina TA; Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, NGA., Okunade KS; Obstetrics and Gynaecology, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Lagos, NGA., Oluwole AA; Obstetrics and Gynaecology, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Lagos, NGA., Anorlu RI; Obstetrics and Gynaecology, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Lagos, NGA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Oct 10; Vol. 13 (10), pp. e18638. Date of Electronic Publication: 2021 Oct 10 (Print Publication: 2021).
DOI:	10.7759/cureus.18638
Abstrakt:	Background: Uterine fibroids significantly affect the quality of life of reproductive-age women. The socioeconomic cost and psychological strain on patients cannot be overemphasized. The role of diet and micronutrients on the onset and development of uterine fibroids has come under review in recent times. This study assessed the levels of some micronutrients and trace elements in the serum of women with uterine fibroids. Methods: Eighty-eight women were recruited from the Gynecology Outpatient Clinic of Lagos University Teaching Hospital, 44 with uterine fibroids and 44 women without uterine fibroids. Blood samples were obtained and analyzed for serum levels of selected micronutrients (vitamins A, C, D, and E) and trace elements (calcium, magnesium, and phosphorus). Pelvic ultrasonography was performed on all study participants. Results: Women with uterine fibroids had statistically significant lower serum levels of vitamin C (1.20 ± 0.59 vs 1.62 ± 1.75 mg/dl; p = 0.01), vitamin D (34.23 ±10.67 vs 37.06 ±11.46 ng/ml; p = 0.04), and calcium (2.27 ± 0.19 vs 2.32 ± 0.09 mmol/L; p = 0.02) compared with women without uterine fibroids. There was no significant difference in the serum levels of vitamins A (39.63 ± 15.71 vs 40.09 ±15.26 μ/dl; p = 0.91), vitamin E (5.44 ± 4.65 vs 5.26 ± 4.62 µg/mL; p = 0.87), magnesium (0.89 ± 0.09 vs 0.89 ± 0.08 mmol/L; p = 0.78), and phosphorus (1.29 ± 0.38 vs 1.19 ± 0.17 mmol/L; p = 0.14) in women with uterine fibroids compared to those without uterine fibroids. Conclusion: This study showed lower serum levels of vitamin C, vitamin D, and calcium in women with uterine fibroids when compared to women without uterine fibroids. It is possible that these micronutrients and trace elements may play a role in the etiopathogenesis, progression, and/or proliferation of uterine fibroids. However, whether the findings of low serum levels of these elements are a cause or an effect of uterine fibroid, is yet to be determined. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Makwe et al.)
Databáze:	MEDLINE
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