Impact of antenatal corticosteroid exposure on thymus size in premature infants.

Autor: Kilicdag H; Division of Neonatology, Department of Pediatrics, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey. Electronic address: hasankilicdag@gmail.com., Torer B; Division of Neonatology, Department of Pediatrics, Baskent University, Adana, Turkey., Demir S; Department of Radiology, Baskent University, Adana, Turkey., Hanta D; Division of Neonatology, Department of Pediatrics, Adana Delivery and Child Disease Hospital, Adana, Turkey., Akbas T; Department of Radiology, Acibadem Hospital, Adana, Turkey., Mert MK; Division of Neonatology, Department of Pediatrics, Numune Education and Research Hospital, Adana, Turkey., Soker G; Department of Radiology, Numune Education and Research Hospital, Adana, Turkey.
Jazyk: angličtina
Zdroj: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2022 Jan; Vol. 29 (1), pp. 67-71. Date of Electronic Publication: 2021 Nov 09.
DOI: 10.1016/j.arcped.2021.09.015
Abstrakt: Background: This study examined the effect of corticosteroids on the thymic index (TI) and the thymus/weight index (TWI) in infants exposed to antenatal corticosteroids (ACS).
Methods: This prospective study was conducted between August 2014 and October 2018. A thymus ultrasound was performed to assess thymus size on the second day of life. Thymus size was assessed as TI and TWI.
Results: In total, 167 neonates (≤34 weeks gestation)  constituted the study population, including 94 ACS-exposed infants and 73 untreated infants. The treatment group exhibited significantly lower birth weight and significantly shorter birth length than the ACS (-) group. Therefore, TI was smaller in the treatment group than in the untreated group (6.96 ± 4.05 cm 3 vs. 5.64 ± 3.39 cm 3 ). The TWI was 3.69 ± 1.8 cm 3 /kg in the ACS (-) group versus 3.32 ± 1.56 cm 3 /kg in the ACS (+) group. The median anteroposterior diameter of the right lobe was 1.33 cm (range, 0.45-2.40) in the ACS (-) group compared to 1.15 cm (range, 0.47-2.40) in the ACS (+) group. The median anteroposterior diameter of the left lobe was 1.40 cm (range, 0.43-2.20) in the ACS (-) group and 1.19 cm (range, 0.32-2.36) in the ACS (+) group. The median largest sagittal area was 2.64 cm 2 (range, 0.5-5.46) in the ACS (-) group versus 2.20 cm 2 (range, 0.55-5.90) in the ACS (+) group.
Conclusion: We found that TWI was not significantly changed by ACS exposure in premature infants.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: