The occurrence of neuropathic pain following surgery of brainstem cavernous malformations.

Autor: Herten A; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Saban D; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Santos AN; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Chen B; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Darkwah Oppong M; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Rauschenbach L; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Jabbarli R; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Wrede K; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Bingel U; Department of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany., Müller D; Department of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany., Holle-Lee D; Department of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Li Y; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany., Sure U; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Dammann P; ¹Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2022 Mar; Vol. 29 (3), pp. 865-872. Date of Electronic Publication: 2021 Dec 01.
DOI: 10.1111/ene.15179
Abstrakt: Background and Purpose: This study aimed to assess the occurrence and significance of postoperative neuropathic pain (NP) in patients with surgically treated brainstem cavernous malformations (BSCMs).
Methods: Seventy-four BSCM patients surgically treated between 2003 and 2019 were reviewed for the occurrence of postoperative NP and related treatment. The relevance of BSCM location, preoperative characteristics, influence on functional outcome, postoperative health-related quality of life (HRQOL) and life satisfaction was evaluated.
Results: Six out of 74 patients (8%) suffered from NP. The Leeds Assessment of Neuropathic Symptoms and Signs scores ranged from 12 to 16 (mean 14.28 ± 1.6). Visual analog scale pain was 5.2 ± 2.0. NP had no effect on preoperative characteristics or functional outcome. Bodily pain (HRQOL) and vocational time (life satisfaction) were significantly decreased in NP compared to non-NP patients. Specific BSCM location (regarding brainstem nuclei involved in pain processing) and other preoperative patient- and BSCM-related parameters were not associated with the occurrence of postoperative NP. Three out of six patients were currently under NP-specific treatment. The proportion of patients suffering from postoperative NP (8%) was substantially higher compared to previously published studies. The pain affected the HRQOL of patients, most of whom were insufficiently treated and not satisfied with treatment results.
Conclusion: Our findings may help to raise awareness for postoperative NP in BSCM, which is essential to improve diagnosis and initiation of proper treatment, as well as preoperative informed consent of patients.
(© 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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