The aging venous system: from varicosities to vascular cognitive impairment.

Autor: Molnár AÁ; Heart and Vascular Center, Semmelweis University, Városmajor Street 68, 1121, Budapest, Hungary. molnarandreaagnes@gmail.com., Nádasy GL; Department of Physiology, Semmelweis University, Budapest, Hungary., Dörnyei G; Department of Morphology and Physiology, Health Sciences Faculty, Semmelweis University, Budapest, Hungary., Patai BB; Department of Traumatology, Military Hospital, Budapest, Hungary., Delfavero J; Vascular Cognitive Impairment and Neurodegeneration Program, Center for Geroscience and Healthy Brain Aging/Reynolds Oklahoma Center On Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Fülöp GÁ; Heart and Vascular Center, Semmelweis University, Városmajor Street 68, 1121, Budapest, Hungary., Kirkpatrick AC; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK, 73104, USA., Ungvári Z; Vascular Cognitive Impairment and Neurodegeneration Program, Center for Geroscience and Healthy Brain Aging/Reynolds Oklahoma Center On Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary., Merkely B; Heart and Vascular Center, Semmelweis University, Városmajor Street 68, 1121, Budapest, Hungary.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2021 Dec; Vol. 43 (6), pp. 2761-2784. Date of Electronic Publication: 2021 Nov 11.
DOI: 10.1007/s11357-021-00475-2
Abstrakt: Aging-induced pathological alterations of the circulatory system play a critical role in morbidity and mortality of older adults. While the importance of cellular and molecular mechanisms of arterial aging for increased cardiovascular risk in older adults is increasingly appreciated, aging processes of veins are much less studied and understood than those of arteries. In this review, age-related cellular and morphological alterations in the venous system are presented. Similarities and dissimilarities between arterial and venous aging are highlighted, and shared molecular mechanisms of arterial and venous aging are considered. The pathogenesis of venous diseases affecting older adults, including varicose veins, chronic venous insufficiency, and deep vein thrombosis, is discussed, and the potential contribution of venous pathologies to the onset of vascular cognitive impairment and neurodegenerative diseases is emphasized. It is our hope that a greater appreciation of the cellular and molecular processes of vascular aging will stimulate further investigation into strategies aimed at preventing or retarding age-related venous pathologies.
(© 2021. The Author(s).)
Databáze: MEDLINE
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