Do Oncologic Outcomes From Head and Neck Versus Truncal and Extremity Melanoma Differ? A Single-Institution Single-Subspecialty Experience.

Autor:	Baecher KM; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Turgeon MK; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Medin CR; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Mahendran G; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Flakes TM; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Delman KA; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA., Lowe MC; Department of Surgery, 1371Emory University School of Medicine, Atlanta, GA, USA.
Jazyk:	angličtina
Zdroj:	The American surgeon [Am Surg] 2022 Mar; Vol. 88 (3), pp. 480-488. Date of Electronic Publication: 2021 Nov 11.
DOI:	10.1177/00031348211050813
Abstrakt:	Background: Outcomes are thought to be worse in head and neck (H&N) melanoma patients. However, definitive evidence of inferior outcomes in H&N melanoma in the modern era is lacking. We sought to ascertain whether H&N melanomas carry a worse prognosis than melanomas of other sites. Methods: All patients who underwent excision for primary melanoma by fellowship-trained surgical oncologists at a single institution from 2014 to 2020 were queried from the electronic medical record. Patients who had AJCC eighth edition stage I-III disease were included. Results: Of 1127 patients, 28.7% had primary H&N melanoma. H&N patients were more likely to be male, older, and present with more advanced AJCC stage. Median follow-up was 20.0 months (IQR 26.4). On multivariable analyses controlling for other variables, H&N melanoma was associated with worse RFS. Notably, H&N melanoma was not associated with worse MSS, DMFS, or OS on univariate or multivariable analyses. Among patients who recurred, H&N patients were significantly more likely to recur locally compared to non-H&N patients. On subgroup analysis, scalp melanoma was also associated with worse RFS compared to patients with melanoma in locations other than the scalp. When patients with scalp melanoma were excluded from analysis, non-scalp H&N RFS was not significantly different from the non-H&N group on univariate or multivariable analyses. Discussion: In this series from a high-volume tertiary referral center, the differences in rates and sites of recurrence between H&N and non-H&N melanoma do not impact melanoma-specific or overall survival, suggesting that H&N melanoma patients should be treated similarly with respect to regional and systemic therapies.
Databáze:	MEDLINE
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