| Autor: |
Summaria F; Division of Cardiology, San Eugenio Hospital, Rome, Italy - f.summaria@gmail.com., Biondi-Zoccai G; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy.; Mediterranea Cardiocentro, Naples, Italy., Romagnoli E; Division of Cardiology, Sacred Heart Catholic University, Rome, Italy., Mamas MA; Keele University, Keele, UK., Franchi F; Division of Cardiology, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA., Severino P; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University, Rome, Italy., Lavalle C; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University, Rome, Italy., Versaci F; Division of Cardiology, Santa Maria Goretti Hospital, Latina, Italy., Gaspardone A; Division of Cardiology, San Eugenio Hospital, Rome, Italy., Bhatt DL; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA. |
| Abstrakt: |
Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAPT) and dual pathway inhibition (DPI), which includes an antiplatelet agent and a reduced dose anticoagulant agent. In selected patients at high risk of event and low risk of bleeding, especially those undergoing recent and complex coronary revascularization using drug-eluting stents (DES) ("revascularization-driven effect"), DAPT is superior to single antiplatelet therapy with aspirin. DPI involves a wider potential range of treatment and is superior to single antiplatelet therapy with aspirin, particularly in patients with atherothrombotic involvement in different vascular beds both previously revascularized and not ("no revascularization-driven effect"). After nearly thirty years of randomized trials and observational registries, we have sufficient data to customize antithrombotic therapy in patients at high cardiovascular risk. Therefore, "atherothrombosis stakeholders" must identify the right patient for the right therapy to ensure high levels of efficacy and safety with the best of current therapeutic opportunities. |
