Oral mucositis-related neuropathic pain in head and neck cancer patients receiving radiotherapy or chemo-radiotherapy. A prospective study.
| Autor: | Kouri M; Clinic of Hospital Dentistry, National and Kapodistrian University of Athens, Dental School, Athens, Greece., Nicolatou Galitis O, Vadalouca A, Kouloulias V, Papadopoulou E, Vardas E, Kyrodimos E, Trichas M, Zygogianni A, Liakouli Z, Galitis E, Siafaka I, Kougioumtzopoulou A, Psyrri A |
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| Jazyk: | angličtina |
| Zdroj: | Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2021 Sep-Oct; Vol. 26 (5), pp. 2010-2018. |
| Abstrakt: | Purpose: Pain due to oral-mucositis (OM) in head and neck cancer (HNC) patients receiving radiotherapy (RT) /chemo-radiotherapy (CRT) can be nociceptive and/or neuropathic. Neuropathic pain (NP) often remains underdiagnosed and untreated. This study's purpose was to identify the presence of OM-induced NP in HNC patients under RT/CRT. Methods: Pain was assessed using a 0-10 numeric scale (NRS). At an NRS≥5 score, patients completed the Douleur Neuropathique 4 (DN4) questionnaire, where a score ≥4/10 indicates the presence of NP. Mucositis and xerostomia were assessed using the European Organization for Research and Treatment of Cancer and the NRS scales accordingly. Pain medication was documented. Results: Forty patients were recruited; twenty-six (mean age 63.54±13.96 years) completed a DN4 (mean pain NRS 7.46±1.42); five (5/26, 19.23%) had a DN4≥4. The most common NP descriptors were "burning" (34.62%), "electric shocks" (30.77%) and "pins-and-needles" (30.77%). A direct correlation was observed between DN4 and pain, mucositis, and xerostomia (p<0.02). Pain medication was administered to fifteen patients (15/26, 57.69%). Adjuvant medication was administered to one patient with positive DN4 score. Conclusions: Five (5/26, 19%) of the patients with NRS≥5 developed NP; adjuvant medication to address NP was prescribed to one patient. NP is likely underdiagnosed and undertreated in the HNC population undergoing RT/RC. |
| Databáze: | MEDLINE |
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