EVALI Vaping Liquids Part 2: Mass Spectrometric Identification of Diluents and Additives.

Autor:	Ciolino LA; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States., Falconer TM; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States., Ranieri TL; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States., Brueggemeyer JL; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States., Taylor AM; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States., Mohrhaus AS; Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, OH, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in chemistry [Front Chem] 2021 Oct 25; Vol. 9, pp. 746480. Date of Electronic Publication: 2021 Oct 25 (Print Publication: 2021).
DOI:	10.3389/fchem.2021.746480
Abstrakt:	The vaping liquid additive vitamin E acetate (VEA) was strongly linked to the 2019 United States nationwide outbreak of pulmonary lung illness (EVALI) associated with e-cigarettes or vaping liquids. Our laboratory received over 1,000 vaping liquid products for identification of the vaping liquid additives, including hundreds of vaping products from EVALI patients. In this work, we present results obtained for the GC-MS identification of numerous vaping liquid additives in a large subset of ca. 300 Cannabis vaping liquids, including vitamin E acetate, medium chain triglycerides oil (MCT oil), polyethylene glycols, squalane, triethyl citrate, dipropylene glycol dibenzoate (DPG dibenzoate), pine rosin acids, pine rosin methyl esters, and sucrose acetate isobutyrate (SAIB). Confirmation of DPG dibenzoate and SAIB using LC-HRMS is also presented. GC-MS analysis for additives identified as the parent compounds was conducted after separation on a commercial 5% phenyl phase. GC-MS analysis for additives identified as the trimethylsilyl derivatives was conducted after separation on a commercial 35% silphenylene phase. LC-HRMS analysis was conducted using gradient elution with either C18 or phenyl-hexyl phases and determination of exact masses for the target compounds. In addition to providing rapid methods for the identification of vaping liquid additives, this work highlights the variety of Cannabis vaping liquid additives in current use. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ciolino, Falconer, Ranieri, Brueggemeyer, Taylor and Mohrhaus.)
Databáze:	MEDLINE
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