A case series of morbid COPD exacerbations during immune checkpoint inhibitor therapy in cancer patients.

Autor:	Nair VS; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA, 98109, USA.; Division of Pulmonary, Critical Care & Sleep Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA, 98195, USA., Eaton K; Thoracic, Head & Neck Medical Oncology, Seattle Cancer Care Alliance, 1354 Aloha St, Seattle, WA, 98109, USA.; Division of Medical Oncology, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA, 98195, USA., McGarry Houghton A; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA, 98109, USA.; Division of Pulmonary, Critical Care & Sleep Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA, 98195, USA.
Jazyk:	angličtina
Zdroj:	Respiratory medicine case reports [Respir Med Case Rep] 2021 Oct 23; Vol. 34, pp. 101541. Date of Electronic Publication: 2021 Oct 23 (Print Publication: 2021).
DOI:	10.1016/j.rmcr.2021.101541
Abstrakt:	Background: Immune checkpoint inhibitor therapy is rapidly becoming front line adjuvant or primary therapy in a number of solid cancer types. Since many of these cancers are a result of tobacco smoking, a large number of these patients will have underlying comorbid conditions attributed to smoking such as Chronic Obstructive Pulmonary Disease (COPD). The effect of immune checkpoint inhibitor therapy on COPD is not well documented, and COPD exacerbations are not currently considered a pulmonary associated immune checkpoint inhibitor toxicity in current guidelines. Case Presentation: We describe and summarize here a series of patients with prolonged and severe COPD exacerbations upon the initiation of immune checkpoint inhibitor therapy for cancers of the skin and lung without radiographic evidence of pneumonitis. Conclusions: COPD exacerbation from immune checkpoint inhibitor is not reported in the literature and is associated with prolonged and severe episodes without radiographic evidence of pneumonitis. Awareness of this potential morbid toxicity and research efforts to understand its etiology are required. Competing Interests: The authors declare no conflicts of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
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