| Autor: |
Wenzel BE, Arnholdt H, Grammerstorf S, Gutekunst R, Scriba PC |
| Jazyk: |
angličtina |
| Zdroj: |
Acta endocrinologica. Supplementum [Acta Endocrinol Suppl (Copenh)] 1987; Vol. 281, pp. 21-6. |
| DOI: |
10.1530/acta.0.114s021 |
| Abstrakt: |
The modulation of HLA-D expression of thyroid epithelial cells (TEC) was studied in vitro by means of immunofluorescence. Under serum-free culture conditions, TSH and TSH-receptor antibodies induce HLA-D on TECs derived from GD-patients. Serum-free culture conditions provide a higher availability of TSH-receptors by a 'right side right' polarity of the cellular morphology. There was no evidence for IFN-gamma producing cell contaminations on GD-TECs. TSH in contrast to IFN-gamma does not induce HLA-DQ on TECs. HLA-DQ is not displayed by spontaneously class-II antigen expressing GD-TECs. Methimazole as well as perchlorate do not suppress HLA-D expression of TECs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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