| Autor: |
Nguyen TQ; Faculty of Environmental Science, Sai Gon University, Ho Chi Minh City, Vietnam., Pham NK; Faculty of Environmental Science, Sai Gon University, Ho Chi Minh City, Vietnam., Trung NT; Laboratory of Computational Chemistry and Modelling (LCCM), Quy Nhon University, Quy Nhon, Vietnam., An NT; Laboratory of Computational Chemistry and Modelling (LCCM), Quy Nhon University, Quy Nhon, Vietnam., Mai DT; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Sichaem J; Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand., Huynh BL; Department of Nature, Dong Nai University, Biên Hòa, Dong Nai, Vietnam., Anh NTH; Ho Chi Minh City University of Food Industry, 140 Le Trong Tan Street, Tay Thanh Ward, Tan Phu District, HCMC, Vietnam., Nguyen NH; CirTech Institute, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam., Duong TH; Department of Chemistry, University of Education, Ho Chi Minh City, Vietnam. |
| Abstrakt: |
One new hopane-type triterpene, indicuen ( 1 ), along with eight known compounds ( 2-9 ) were isolated from the n -hexane extract of the lichen Parmotrema indicum Hale. The chemical structures of isolated compounds were identified by interpretation of their spectroscopic data (1D, 2D NMR and HRESIMS) combined with DFT-NMR chemical shift calculations and subsequent assignment of DP4+ probabilities and by comparison with the literature. Indicuen represents for a rare hopane bearing a 1-carboxyethyl substituent at C-21 in lichens. Compounds 1-3 and 5 - 8 were evaluated for α -glucosidase inhibition and cytotoxicity against K562 and HepG2 cancer cell lines. Compounds 1 , 5 and 7 exhibited moderate α -glucosidase inhibition with IC 50 values of 201.1, 156.3 and 187.4 µM, respectively. Compound 1 also showed weak cytotoxicity toward K562 cell line while others showed no activity. |
