[The screening of potential biological markers of seizure onset zone in focal cortical dysplasia based on bioinformatics analysis].

Autor:	Sun Y; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China., Wang DM; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China., Yu H; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China., Liu C; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China., Ji TY; Department of Pediatrics, Peking University First Hospital, Beijing 100034, China., Wang S; Department of Pediatrics, Peking University First Hospital, Beijing 100034, China., Wu Y; Department of Pediatrics, Peking University First Hospital, Beijing 100034, China., Liu XY; Department of Pediatrics, Peking University First Hospital, Beijing 100034, China., Jiang YW; Department of Pediatrics, Peking University First Hospital, Beijing 100034, China., Cai LX; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China., Liu QZ; Pediatric Epilepsy Center, Peking University First Hospital, Beijing 100034, China.
Jazyk:	čínština
Zdroj:	Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2021 Nov 09; Vol. 101 (41), pp. 3422-3426.
DOI:	10.3760/cma.j.cn112137-20210331-00779
Abstrakt:	Three patients diagnosed with focal cortical dysplasia (FCD) in the First Hospital of Peking University from September to November 2020 were recruited in the study. Based on stereotactic electroencephalogram (SEEG) or electrocorticogram (ECoG) analysis to localize the seizure onset zone (SOZ), RNA sequencing (RNA-seq) analysis was performed for the SOZ and para-SOZ tissue obtained from surgery. The differentially expressed genes between SOZ and para-SOZ samples were analyzed by performing Go (Gene ontology) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis."Extracellular matrix"was significantly enriched, which included collagen synthesis genes (e.g., COL1A1)."Ether lipid metabolism"was enriched in the KEGG pathway enrichment analysis. These differences could be the potential biological markers for SOZ localization.
Databáze:	MEDLINE
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