Gonadotropin-inhibitory hormone as a regulator of social interactions in vertebrates.

Autor: Tobari Y; Laboratory of Animal Genetics and Breeding, Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Fuchinobe 1-17-71, Chuo-ku, Sagamihara City 252-5201, Japan; Center for Human and Animal Symbiosis Science, Azabu University, Fuchinobe 1-17-71, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. Electronic address: tobari@azabu-u.ac.jp., Aleksandrova Y; The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK., Fukahori Y; Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan., Tsutsui K; Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan; Graduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama 1-7-1, Higashi-Hiroshima 739-8521, Japan., Meddle SL; The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Jazyk: angličtina
Zdroj: Frontiers in neuroendocrinology [Front Neuroendocrinol] 2022 Jan; Vol. 64, pp. 100954. Date of Electronic Publication: 2021 Oct 29.
DOI: 10.1016/j.yfrne.2021.100954
Abstrakt: The social environment changes circulating hormone levels and expression of social behavior in animals. Social information is perceived by sensory systems, leading to cellular and molecular changes through neural processes. Peripheral reproductive hormone levels are regulated by activity in the hypothalamic-pituitary-gonadal (HPG) axis. Until the end of the last century, the neurochemical systems that convey social information to the HPG axis were not well understood. Gonadotropin-inhibitory hormone (GnIH) was the first hypothalamic neuropeptide shown to inhibit gonadotropin release, in 2000. GnIH is now regarded as a negative upstream regulator of the HPG axis, and it is becoming increasingly evident that it responds to social cues. In addition to controlling reproductive physiology, GnIH seems to modulate the reproductive behavior of animals. Here, we review studies investigating how GnIH neurons respond to social information and describe the mechanisms through which GnIH regulates social behavior.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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