Effects of partial- or whole-body exposures to 56 Fe particles on brain function and cognitive performance in rats.

Autor: Cahoon DS; USDA-ARS, Human Nutrition Research Center on Aging at Tufts Univ., Boston, MA 02111, USA., Shukitt-Hale B; USDA-ARS, Human Nutrition Research Center on Aging at Tufts Univ., Boston, MA 02111, USA., Bielinski DF; USDA-ARS, Human Nutrition Research Center on Aging at Tufts Univ., Boston, MA 02111, USA., Hawkins EM; Department of Psychology, UMBC, Baltimore, MD 21250, USA., Cacioppo AM; Department of Psychology, UMBC, Baltimore, MD 21250, USA., Rabin BM; Department of Psychology, UMBC, Baltimore, MD 21250, USA. Electronic address: rabin@umbc.edu.
Jazyk: angličtina
Zdroj: Life sciences in space research [Life Sci Space Res (Amst)] 2020 Nov; Vol. 27, pp. 56-63. Date of Electronic Publication: 2020 Jul 24.
DOI: 10.1016/j.lssr.2020.07.006
Abstrakt: On exploratory class missions, such as a mission to Mars, astronauts will be exposed to particles of high energy and charge (HZE particles). Exposure to HZE particles produces changes in neuronal function and can disrupt cognitive performance. Cells throughout the entire body, not just the brain, will be impacted by these particles. To determine the possible effects that irradiation of the body might have on neuronal function and cognitive performance, rats were given head-only, body-only or whole-body exposures to 56 Fe particles. Cognitive performance (novel object recognition, operant responding) was tested in one set of animals; changes in brain function (oxidative stress, neuroinflammation) was tested in a second set of rats. The results indicated that there were no consistent differences in either behavioral or neurochemical endpoints as a function of the location of the irradiation. These results suggest that radiation to the body can impact the brain, therefore it may be necessary to re-evaluate the estimates of the risk of HZE particle-induced changes in neuronal function and cognitive performance.
(Copyright © 2020. Published by Elsevier Ltd.)
Databáze: MEDLINE
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