Safety of autologous fat grafting in breast cancer: a multicenter Italian study among 17 senonetwork breast units autologous fat grafting safety: a multicenter Italian retrospective study.

Autor: Klinger M; Reconstructive and Aesthetic Plastic Surgery School, Department of Medical Biotechnology and Translational Medicine BIOMETRA - Plastic Surgery Unit, University of Milan, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Losurdo A; UO of Medical Oncology, Department of Oncology and Hematology, Humanitas Clinical and Research Center, IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy. agnese.losurdo@humanitas.it., Lisa AVE; Reconstructive and Aesthetic Plastic Surgery School, Department of Medical Biotechnology and Translational Medicine BIOMETRA - Plastic Surgery Unit, University of Milan, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Morenghi E; Biostatistics Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Vinci V; Reconstructive and Aesthetic Plastic Surgery School, Department of Medical Biotechnology and Translational Medicine BIOMETRA - Plastic Surgery Unit, University of Milan, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Corsi F; Department of Biomedical and Clinical Sciences, 'Luigi Sacco', Università di Milano, Milan, Italy.; Department of Surgery, Breast Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy., Albasini S; Department of Surgery, Breast Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy., Leonardi MC; Division of Radiotherapy, IEO, European Institute of Oncology IRCCS, Milan, Italy., Jereczek-Fossa BA; Division of Radiotherapy, IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy., Veronesi P; Department of Oncology and Hematology, University of Milan, Milan, Italy.; Division of Breast Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy., Rietjens M; Division of Plastic and Reconstructive Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy., Fabiocchi L; Plastic Surgery Unit, Breast Unit, Rimini Santarcangelo Hospital, Rimini, Italy., Santicchia S; Department of Breast Diagnosis, Breast Unit, Rimini Santarcangelo Hospital, Rimini, Italy., Klinger F; University of Milan, Reconstructive and Aesthetic Plastic Surgery School - MultiMedica Holding S.p.A.- Plastic Surgery Unit - Sesto San Giovanni, Milan, Italy., Loreti A; Department of Plastic and Reconstructive Surgery, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Fortunato L; Breast Surgery Unit, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Bocchiotti MA; Department of Plastic and Reconstructive Surgery, Università Città della Salute e della Scienza, Torino, Italy., Nicolò FA; Department of Plastic and Reconstructive Surgery, Università Città della Salute e della Scienza, Torino, Italy., Stringhini P; Reconstructive Surgery, Fondazione Poliambulanza Brescia, Brescia, Italy., Parodi PC; Department of Medical, Experimental and Clinical Sciences - Plastic and Aesthetic Surgery, University of Udine, Udine, Italy., Rampino E; Department of Medical, Experimental and Clinical Sciences - Plastic and Aesthetic Surgery, University of Udine, Udine, Italy., Guarneri V; UO of Clinical Oncology, Università di Padova, Istituto Oncologico Veneto IRCCS, Padova, Italy.; Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Pagura G; Breast Unit, ULSS3 Serenissima, Mestre, Italy., Venezia ED; Department of Plastic and Reconstructive Surgery, ULSS3 Serenissima, Mestre, Italy., Meneghini G; Breast Unit, Azienda ULSS8 Berica, Vicenza, Montecchio Maggiore, Italy., Kraljic T; Breast Unit, Azienda ULSS8 Berica, Vicenza, Montecchio Maggiore, Italy., Persichetti P; Department of Plastic and Reconstructive Surgery, Medico University of Rome, Campus Bio, Rome, Italy., Barone M; Department of Plastic and Reconstructive Surgery, Medico University of Rome, Campus Bio, Rome, Italy., Vaia N; Department of Plastic and Reconstructive Surgery, Belcolle Hospital, Viterbo, Italy., Zerini I; Department of Plastic and Reconstructive Surgery, Azienda Ospedaliera Universitaria Senese, Siena, Italy., Grimaldi L; Department of Plastic and Reconstructive Surgery, Azienda Ospedaliera Universitaria Senese, Siena, Italy., Riccio M; Department of Plastic and Reconstructive Hand Surgery, AOU Ospedali Riuniti di Ancona, Ancona, Italy., Aquinati A; Regenerative Surgery Research and Formation Center, Accademia del Lipofilling, Montelabbate, Italy., Bassetto F; Clinic of Plastic and Reconstructive Surgery, Department of Neurosciences, University of Padova, Padova, Italy., Vindigni V; Clinic of Plastic and Reconstructive Surgery, Department of Neurosciences, University of Padova, Padova, Italy., Ciuffreda L; Breast Surgery Unit, IRCCS Fondazione Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Tinterri C; Breast Surgery Department, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Santoro A; UO of Medical Oncology, Department of Oncology and Hematology, Humanitas Clinical and Research Center, IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Jazyk: angličtina
Zdroj: Breast cancer research and treatment [Breast Cancer Res Treat] 2022 Jan; Vol. 191 (2), pp. 355-363. Date of Electronic Publication: 2021 Nov 09.
DOI: 10.1007/s10549-021-06444-9
Abstrakt: Background: Autologous fat grafting (AFG), defined as the re-implant to the breast of fat tissue from different body areas, has been firstly applied to esthetic plastic surgery and then has moved to reconstructive surgery, mainly used for scar correction and opposite breast altering. Nevertheless, due to the potentially unsafe stem-like properties of adipocytes at the tumoral bed level, no clear evidence of the procedure's oncological safety has been clearly documented at present.
Patients and Methods: We retrospectively collected data of early breast cancer (BC) patients from 17 Italian Breast Units and assessed differences in terms of locoregional recurrence rate (LRR) and locoregional recurrence-free survival (LRFS) between patients who underwent AFG and patients who did not. Differences were analyzed in the entire cohort of invasive tumors and in different subgroups, according to prognostic biological subtypes.
Results: With a median follow-up time of 60 months, LRR was 5.3% (n = 71) in the matched population, 3.9% (n = 18) in the AFG group, and 6.1% (n = 53) in the non-AFG group, suggesting non-inferiority of AFG (p = 0.084). Building Kaplan-Meier curves confirmed non-inferiority of the AFG procedure for LRFS (aHR 0.73, 95% CI 0.41-1.30, p = 0.291). The same effect, in terms of LRFS, was also documented among different biological subtypes (luminal-like group, aHR 0.76, 95% CI 0.34-1.68, p = 0.493; HER2 enriched-like, aHR 0.89, 95% CI 0.19-4.22, p = 0.882; and TNBC, aHR 0.61, 95% CI 0.12-2.98, p = 0.543).
Conclusions: Our study confirms in a very large, multicenter cohort of early BC patients that, aside the well-known benefits on the esthetic result, AFG do not interfere negatively with cancer prognosis.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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