AdipoAtlas : A reference lipidome for human white adipose tissue.

Autor:	Lange M; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany., Angelidou G; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany., Ni Z; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany., Criscuolo A; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany.; Thermo Fisher Scientific, Dreieich, Germany., Schiller J; Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Leipzig, Germany., Blüher M; Medical Department III (Endocrinology, Nephrology and Rheumatology), University of Leipzig, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Fedorova M; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany.
Jazyk:	angličtina
Zdroj:	Cell reports. Medicine [Cell Rep Med] 2021 Sep 22; Vol. 2 (10), pp. 100407. Date of Electronic Publication: 2021 Sep 22 (Print Publication: 2021).
DOI:	10.1016/j.xcrm.2021.100407
Abstrakt:	Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodeling at the molecular level, we provide in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. We generate a human WAT reference lipidome by performing tissue-tailored preanalytical and analytical workflows, which allow accurate identification and semi-absolute quantification of 1,636 and 737 lipid molecular species, respectively. Deep lipidomic profiling allows identification of main lipid (sub)classes undergoing depot-/phenotype-specific remodeling. Previously unanticipated diversity of WAT ceramides is now uncovered. AdipoAtlas reference lipidome serves as a data-rich resource for the development of WAT-specific high-throughput methods and as a scaffold for systems medicine data integration. Competing Interests: M.B. received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no competing interests. (© 2021 The Author(s).)
Databáze:	MEDLINE
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