In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells.

Autor: Zerbinati N; Department of Medicine and Surgery, University of Insubria, Varese 21100, Italy., Sommatis S; UB-CARE S.r.l., Spin-off University of Pavia, Pavia 27100, Italy., Maccario C; UB-CARE S.r.l., Spin-off University of Pavia, Pavia 27100, Italy., Capillo MC; UB-CARE S.r.l., Spin-off University of Pavia, Pavia 27100, Italy., Di Francesco S; UB-CARE S.r.l., Spin-off University of Pavia, Pavia 27100, Italy., Rauso R; Department of Maxillofacial Surgery, University of Campania 'Luigi Vanvitelli', Caserta 81100, Italy., Protasoni M; Department of Medicine and Surgery, University of Insubria, Varese 21100, Italy., D'Este E; Department of Dermatology, Centro Medico Polispecialistico, Pavia 27100, Italy., Gasperina DD; Department of Medicine and Surgery, University of Insubria, Varese 21100, Italy., Mocchi R; UB-CARE S.r.l., Spin-off University of Pavia, Pavia 27100, Italy.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2021 Oct 31; Vol. 2021, pp. 5598110. Date of Electronic Publication: 2021 Oct 31 (Print Publication: 2021).
DOI: 10.1155/2021/5598110
Abstrakt: Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiogenesis are considered two of the basal mechanisms to preserve the growth of the hair follicle. In this study, a noncrosslinked hyaluronic acid (HA) filler (HYDRO DELUXE BIO, Matex Lab S.p.A.) containing several amino acids was tested with in vitro assays on human follicle dermal papilla cells (HFDPCs). The experiments were carried out to investigate the possible protection against oxidative stress and the ability to increase the vascular endothelial growth factor (VEGF) release. The results demonstrated the restoration of cell viability against UVB-induced cytotoxicity and an increase in the VEGF secretion. These data demonstrate the capability of the product to modulate human dermal papilla cells, suggesting a future use in mesotherapy, a minimally invasive local intradermal therapy (LIT), after further clinical investigations.
Competing Interests: Zerbinati N. is the Scientific Director of Matex Lab. The authors declare no other conflicts of interest.
(Copyright © 2021 Nicola Zerbinati et al.)
Databáze: MEDLINE
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