Assay of ethanol and congener alcohols in serum and beverages by headspace gas chromatography/mass spectrometry.

Autor:	Wunder C; Department of Forensic Toxicology, University Hospital, Goethe University, Institute of Legal Medicine, Frankfurt/Main, Germany., Pogoda W; Department of Forensic Toxicology, University Hospital, Goethe University, Institute of Legal Medicine, Frankfurt/Main, Germany., Paulke A; Department of Forensic Toxicology, University Hospital, Goethe University, Institute of Legal Medicine, Frankfurt/Main, Germany., Toennes SW; Department of Forensic Toxicology, University Hospital, Goethe University, Institute of Legal Medicine, Frankfurt/Main, Germany.
Jazyk:	angličtina
Zdroj:	MethodsX [MethodsX] 2021 Oct 29; Vol. 8, pp. 101563. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2021).
DOI:	10.1016/j.mex.2021.101563
Abstrakt:	The analysis of ethanol and of its congeners in blood plays an important role in forensic cases, especially when allegations are made that alcohol has been consumed after an accident. In alcoholic beverages, congener alcohols are by-products and are generated during fermentation. The assay of these compounds in serum samples and beverages has been previously performed using headspace-gas chromatography-flame ionization detection methods (HS-GC-FID). As an alternative, a robust headspace-gas chromatography-mass spectrometry (HS-GC-MS) procedure was developed and validated, which has the following advantages:•Simultaneous determination of ethanol, congener alcohols and other endogenous substances.•Reduction of matrix interference by increasing selectivity and specificity.•Clear separation of the positional isomers 3-methyl-1-butanol and 2-methyl-1-butanol. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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