Validation of AD8-Philippines (AD8-P): A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines.

Autor:	Dominguez JC; Institute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines., de Guzman MFP; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines.; Research and Biotechnology Division, St. Luke's Medical Center, Quezon City 1102, Philippines., Joson MLC; Institute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines.; Department of Neuroscience and Behavioral Medicine, Faculty of Medicine and Surgery, University of Santo Tomas, Manila 1008, Philippines., Fowler K; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines.; Research and Biotechnology Division, St. Luke's Medical Center, Quezon City 1102, Philippines., Natividad BP; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Research and Biotechnology Division, St. Luke's Medical Center, Quezon City 1102, Philippines., Cruz PS; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines., Jiloca JL; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines.; Geriatric Center, St. Luke's Medical Center, Quezon City 1102, Philippines., Mactal PB Jr; Institute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.; Dementia Society of the Philippines, Manila City 1008, Philippines., Dominguez JD; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; St. Luke's College of Medicine William H. Quasha Memorial, Quezon City 1102, Philippines., Domingo J; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; St. Luke's College of Medicine William H. Quasha Memorial, Quezon City 1102, Philippines., Dominguez-Awao JK; Institute for Dementia Care Asia, Quezon City 1102, Philippines.; St. Louis University College of Medicine, Baguio City 2600, Philippines., Reandelar M Jr; Research and Biotechnology Division, St. Luke's Medical Center, Quezon City 1102, Philippines., Javier JR; Department of Linguistics, College of Social Sciences and Philosophy, University of the Philippines, Quezon City 1100, Philippines., Phung T; Department of Neurology, Danish Dementia Research Center, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Galvin JE; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, USA.
Jazyk:	angličtina
Zdroj:	International journal of Alzheimer's disease [Int J Alzheimers Dis] 2021 Oct 31; Vol. 2021, pp. 7750235. Date of Electronic Publication: 2021 Oct 31 (Print Publication: 2021).
DOI:	10.1155/2021/7750235
Abstrakt:	Aim: This study was aimed at validating the Filipino version of AD8 (AD8-P). Methods: Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia. Results: A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3. Conclusion: AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline. Competing Interests: The authors declare no conflict of interest. (Copyright © 2021 Jacqueline C. Dominguez et al.)
Databáze:	MEDLINE
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