[Coronary artery aneurysm in Kawasaki disease and its risk factors : a retrospective study about 65 Tunisian children].

Autor: Ajmi H; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie. Electronic address: hd.ajmi@gmail.com., Ghorbel S; Service de pédiatrie, CHU Farhat Hached, 4031, Sousse, Tunisie., Ezzi O; Service d'épidémiologie, CHU Farhat Hached, 4031, Sousse, Tunisie., Mabrouk S; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie., Mansour K; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie., Kahloul N; Service de pédiatrie, CHU Farhat Hached, 4031, Sousse, Tunisie., Chemli J; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie., Zouari N; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie., Mejaouel H; Service de pédiatrie, CHU Ibn El Jazzar, Kairouan., Boughammoura L; Service de pédiatrie, CHU Farhat Hached, 4031, Sousse, Tunisie., Abroug S; Service de pédiatrie, CHU Sahloul4054, Sousse, Tunisie.
Jazyk: francouzština
Zdroj: Annales de cardiologie et d'angeiologie [Ann Cardiol Angeiol (Paris)] 2022 Apr; Vol. 71 (2), pp. 86-89. Date of Electronic Publication: 2021 Nov 07.
DOI: 10.1016/j.ancard.2021.10.011
Abstrakt: Introduction: Kawasaki syndrome (KS) is a systemic vasculitis of unknown etiology that affects medium and small blood vessels. The aim of our study is to analyze coronary artery lesions in children with KS and their risk factors.
Material and Methods: All children under the age of 15 years-old presenting KS and admitted in the pediatric department of three university hospital (Sahloul hospital, and Farhat Hached hospital of Sousse, Ibn El Jazzar hospital of Kairoun) from January 2000 to December 2018 were included.
Results: Sixty-five patients were included in our study. The mean age at diagnosis was of 29.9 months [2-120 months] and the sex ratio was of 1.7. Echocardiography was performed in all patients. It showed coronary dilation in 37% of patients with coronary artery diameter of 4.2 mm on average [3.2-7mm]. The coronary aneurysm was small in 19 cases and medium in 5 cases. No giant aneurysm has been identified. In univariate analysis, the predictors of coronary artery lesions were male sex, atypical form, fever duration more than 10 days, hepatic cytolysis, thrombocytosis and anemia. In multivariate analysis, only the last four parameters were the predictive factors of the coronary artery involvement.
Conclusion: Several risk factors can be used to determine which children are predisposed to develop coronary dilations. In case of patient with risk factors, intravenous immunoglobulins should be initiated early to avoid these serious complications.
(Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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