A review of surface-enhanced Raman spectroscopy in pathological processes.

Autor: Kozik A; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia; Siberian Medical State University, Moskovskiy Trakt, 2, Tomsk, 634050, Russia., Pavlova M; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia; Siberian Medical State University, Moskovskiy Trakt, 2, Tomsk, 634050, Russia., Petrov I; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia., Bychkov V; Tomsk National Research Medical Center of the Russian Academy of Sciences, Cancer Research Institute, 5 Kooperativny Street, Tomsk, 634009, Russia., Kim L; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia., Dorozhko E; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia., Cheng C; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China., Rodriguez RD; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia. Electronic address: raul@tpu.ru., Sheremet E; Tomsk Polytechnic University, Lenin Ave, 30, Tomsk, 634050, Russia.
Jazyk: angličtina
Zdroj: Analytica chimica acta [Anal Chim Acta] 2021 Dec 01; Vol. 1187, pp. 338978. Date of Electronic Publication: 2021 Aug 25.
DOI: 10.1016/j.aca.2021.338978
Abstrakt: With the continuous growth of the human population and new challenges in the quality of life, it is more important than ever to diagnose diseases and pathologies with high accuracy, sensitivity and in different scenarios from medical implants to the operation room. Although conventional methods of diagnosis revolutionized healthcare, alternative analytical methods are making their way out of academic labs into clinics. In this regard, surface-enhanced Raman spectroscopy (SERS) developed immensely with its capability to achieve single-molecule sensitivity and high-specificity in the last two decades, and now it is well on its way to join the arsenal of physicians. This review discusses how SERS is becoming an essential tool for the clinical investigation of pathologies including inflammation, infections, necrosis/apoptosis, hypoxia, and tumors. We critically discuss the strategies reported so far in nanoparticle assembly, functionalization, non-metallic substrates, colloidal solutions and how these techniques improve SERS characteristics during pathology diagnoses like sensitivity, selectivity, and detection limit. Moreover, it is crucial to introduce the most recent developments and future perspectives of SERS as a biomedical analytical method. We finally discuss the challenges that remain as bottlenecks for a routine SERS implementation in the medical room from in vitro to in vivo applications. The review showcases the adaptability and versatility of SERS to resolve pathological processes by covering various experimental and analytical methods and the specific spectral features and analysis results achieved by these methods.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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