| Autor: |
Hicks KL; Laboratory Animal Resource Center, University of California, San Francisco, California., Roche E; Laboratory Animal Resource Center, University of California, San Francisco, California., Wilkerson JD; Laboratory Animal Resource Center, University of California, San Francisco, California., Lindstrom KE; Laboratory Animal Resource Center, University of California, San Francisco, California. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Association for Laboratory Animal Science : JAALAS [J Am Assoc Lab Anim Sci] 2021 Nov 01; Vol. 60 (6), pp. 630-636. Date of Electronic Publication: 2021 Nov 09. |
| DOI: |
10.30802/AALAS-JAALAS-21-000056 |
| Abstrakt: |
Fenbendazole is a broad-spectrum benzimidazole commonly used in laboratory animal medicine as an anthelmintic for elimination of pinworms. This drug is generally regarded as safe, with minimal side effects. Some data in rodent species indicate multiple physiologic effects of fenbendazole, including changes in immune parameters and behavior, but no studies to date have evaluated possible effects on reproduction in mice. The purpose of the current study was to determine the effects of several treatment regimens of fenbendazole on reproductive parameters in C57BL/6J mice. Uninfected mice were given fenbendazole-treated feed continuously or every other week until pups were born or weaned. This treatment also was combined with environmental decontamination. No significant differences in litter size, survival rate, or weaning weight were detected between groups. Under the conditions of this study, fenbendazole treatment does not affect reproduction in C57BL/6J mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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