| Autor: |
Dos Santos Oliveira NC; National Institute of Woman, Child, and Adolescence Health Fernandes Figueira, PPGSCM/IFF/FIOCRUZ, Rio de Janeiro, Brazil.; Department of Violence and Health Studies Jorge Careli, National School of Public Health, Rio de Janeiro, Brazil., Serpeloni F; Department of Violence and Health Studies Jorge Careli, National School of Public Health, Rio de Janeiro, Brazil., Gonçalves de Assis S; National Institute of Woman, Child, and Adolescence Health Fernandes Figueira, PPGSCM/IFF/FIOCRUZ, Rio de Janeiro, Brazil.; Department of Violence and Health Studies Jorge Careli, National School of Public Health, Rio de Janeiro, Brazil.; Neurology Post-Gradate Program, Federal University of State of Rio de Janeiro, Unirio, Rio de Janeiro, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of environmental health research [Int J Environ Health Res] 2023 Jan; Vol. 33 (1), pp. 54-70. Date of Electronic Publication: 2021 Nov 09. |
| DOI: |
10.1080/09603123.2021.2000590 |
| Abstrakt: |
Epigenetic marks, particularly DNA methylation (DNAm), are emerging as an important biological marker of susceptibility to cardiac autonomic dysfunction. This review summarizes recent discoveries about the association between DNAm and cardiac autonomic activity. A systematic literature search was performed through the Embase, Web of Science, Cochrane Library, Pubmed, PsycINFO, and Pilots databases. Twenty-two studies met inclusion criteria, of which 18 were human studies including a total of 2,686 participants. DNAm differences in multiple genes, such as NR3C1, TLR2, GPR133, EPO, PHGDH, OXTR , and SLC7A11 , linked environmental stressors to physiological responses. For instance, exposure to psychosocial stressors increased NR3C1 methylation, which was associated with both decreased blood pressure and increased parasympathetic activity. Additionally, GPR133 played a potential role in cardiac autonomic dysfunction in an occupational setting, affecting the heart rate's deceleration capacity in welders. This review's findings suggest that DNAm is involved in cardiac autonomic regulation under different stress-mediated responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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