Biochemical and respiratory parameters in a gastropod Radix balthica exposed to diclofenac.

Autor: Morozov AA; Papanin Institute for Biology of Inland Waters Russian Academy of Sciences, Borok 152742, Russia. Electronic address: aleksey.a.morozov@gmail.com., Berezina NA; Zoological Institute of Russian Academy of Sciences, Universitetskaya emb. 1, St.-Petersburg 199034, Russia., Sladkova SV; St Petersburg Federal Research Center of the Russian Academy of Sciences, 14th Line V.O. 39, St. Petersburg 199178, Russia; St. Petersburg State University, Universitetskaya emb. 7-9, St. Petersburg 199034, Russia., Chernova EN; St Petersburg Federal Research Center of the Russian Academy of Sciences, 14th Line V.O. 39, St. Petersburg 199178, Russia., Yurchenko VV; Papanin Institute for Biology of Inland Waters Russian Academy of Sciences, Borok 152742, Russia.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2022 Feb; Vol. 252, pp. 109240. Date of Electronic Publication: 2021 Nov 06.
DOI: 10.1016/j.cbpc.2021.109240
Abstrakt: Diclofenac, an anti-inflammatory drug, is often detected in natural waters in the ng/L to μg/L range, posing a threat to aquatic organisms. The study focused on the effects of diclofenac in a gastropod mollusk Radix balthica. A 72-h exposure to environmentally relevant concentrations of diclofenac caused deviations from the baseline activities of the studied enzymes in the digestive gland of snails. Acetylcholinesterase activity was induced by the end of exposure, with the most pronounced increase at 3 μg/L. Results on glutathione-S-transferase activity were nonuniform, and no significant variations were observed in thiobarbituric acid reactive substances concentrations, indicating that diclofenac did not cause oxidative stress in the digestive gland of R. balthica at 0.04-4 μg/L range. Diclofenac lowered the oxygen consumption rate in snails in a concentration-dependent manner. At concentrations ≥0.9 μg/L, animals attempted to switch aquatic respiration to breathing air to regulate their metabolic needs. The study showed that diclofenac at environmentally relevant concentrations affected the fitness of R. balthica.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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