Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system.

Autor:	Kwon Y; Department of Medicine, University of Washington, Seattle, Washington., Baruch M; Caretaker Medical Inc., Stafford PL; Department of Medicine., Bonner H; Department of Medicine., Cho Y; Department of Medicine, University of Washington, Seattle, Washington., Mazimba S; Department of Medicine., Logan JG; School of Nursing, University of Virginia, Charlottesville, Virginia., Shimbo D; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Park SH; Division of Cardiology, Yonsei University, Seoul, Korea., Lin GM; Hualien Armed Forces General Hospital, Hualien, and Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Azarbarzin A; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Calhoun DA; Sentara Martha Jefferson Hospital, Charlottesville, Virginia., Berry R; Division of Pulmonary, Critical Care and Sleep, Department of Medicine, University of Florida, Gainesville, Florida, USA., Carey RM; Department of Medicine.
Jazyk:	angličtina
Zdroj:	Journal of hypertension [J Hypertens] 2022 Mar 01; Vol. 40 (3), pp. 520-527.
DOI:	10.1097/HJH.0000000000003041
Abstrakt:	Background: Obstructive sleep apnoea (OSA) episode related blood pressure (BP) surge may mediate the association of OSA with cardiovascular disease. However, BP is not measured during a clinical sleep study. Method: We tested the feasibility of incorporating the Caretaker physiological monitor, which utilizes a novel continuous beat-to-beat (b-b) BP monitoring technology, into polysomnography (PSG) and aimed to characterize BP surges related to obstructive respiratory events. B-b BP was concurrently collected and merged with PSG data on a posthoc basis. We compared BP surge between mean respiratory (apnoea, hypopnea and desaturation-alone events) and nonrespiratory events (spontaneous or leg movement-related arousals). We examined the association of the degree of oxygen desaturation with BP surge in a given respiratory event combining all events. A total of 17 consecutive patients (12 men, mean 52 years old, nine diagnostic and eight split-night PSGs) undergoing clinically indicated PSG were included after excluding one patient with poor signal quality due to excessive movement. Results: Caretaker was well tolerated. Mean respiratory BP surge ranged from 5 to 19 mmHg [Median (IQR) = 13.9 (9.5--16.2)]. Mean BP surge between the respiratory and nonrespiratory events was similar [13.8 (4.5) vs. 14.9 (5.3) mmHg, P = 0.13]. Accounting for the count distribution of desaturation/BP surge data pair events, there was a linear correlation between the degree of oxygen desaturation and BP surge (R = 0.57, P < 0.001). In eight patients undergoing split-night sleep studies, the number of BP surge events (≥10 mmHg/h) decreased during continuous positive airway pressure in all but one patient. Conclusion: We demonstrated highly variable OSA-related BP surge patterns using the Caretaker's b-b BP monitoring technology that has the potential to be integrated into sleep studies. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu