Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast.
| Autor: | Kaya A; Department of Biology, Virginia Commonwealth University, Richmond, United States., Phua CZJ; Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lee M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Wang L; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, United States., Tyshkovskiy A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russian Federation., Ma S; Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Barre B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States., Liu W; Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, Institute of Zoology, Beijing, China., Harrison BR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Zhao X; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Zhou X; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States., Wasko BM; Department of Biology, University of Houston - Clear Lake, Houston, United States., Bammler TK; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, United States., Promislow DE; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.; Department of Biology, University of Washington, Seattle, United States., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2021 Nov 09; Vol. 10. Date of Electronic Publication: 2021 Nov 09. |
| DOI: | 10.7554/eLife.64860 |
| Abstrakt: | To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms underlying natural variation in lifespan. Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan (RLS). Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in RLS across wild yeast isolates, as well as genes, metabolites, and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism, and mitochondrial function in long-lived strains. Overall, our multiomic and lifespan analyses across diverse isolates of the same species shows how gene-environment interactions shape cellular processes involved in phenotypic variation such as lifespan. Competing Interests: AK, CP, ML, LW, AT, SM, BB, WL, BH, XZ, XZ, BW, TB, DP, VG No competing interests declared, MK Reviewing editor, eLife (© 2021, Kaya et al.) |
| Databáze: | MEDLINE |
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