Design and validation of a predictive equation to estimate unbound valproic acid concentration.
Autor: | Conde Giner S; Pharmacy Department, Hospital General de Castellón, Castellon de la Plana, Spain silviacondeginer@gmail.com., Belles Medall MD; Pharmacy Department, Hospital General de Castellón, Castellon de la Plana, Spain., Ferrando Piqueres R; Pharmacy Department, Hospital General de Castellón, Castellon de la Plana, Spain. |
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Jazyk: | angličtina |
Zdroj: | European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2023 Sep; Vol. 30 (5), pp. 293-296. Date of Electronic Publication: 2021 Nov 08. |
DOI: | 10.1136/ejhpharm-2021-003092 |
Abstrakt: | Objectives: Total plasma levels of valproic acid (VPA) may mask an increased risk of adverse effects in hypoalbuminaemic patients since, in these patients, the free fraction is higher. The aim of this study is to analyse the relationship between plasma levels of total and free VPA ( Methods: This is a retrospective observational study conducted between January 2015 and January 2020. Hypoalbuminaemic adult patients with normal renal function were included. Serum VPA levels were determined using an automated enzyme immunoassay technique with a pre-treatment of the sample by ultrafiltration for the quantification of Results: We included 51 determinations, corresponding to 33 patients: 26 in the regression group, and 25 in the validation group. The multiple linear regression analysis showed a statistically significant relationship between Conclusions: The calculated equation adequately predicts Competing Interests: Competing interests: None declared. (© European Association of Hospital Pharmacists 2023. No commercial re-use. See rights and permissions. Published by BMJ.) |
Databáze: | MEDLINE |
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