Characteristics of an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury-North Carolina, 2019.

Autor:	Tanz LJ; Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, Atlanta, Georgia; epidemic intelligence service officer, Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina. ltanz@cdc.gov., Christensen A; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina., Knuth KB; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina; CSTE applied epidemiology fellow, Council of State and Territorial Epidemiologists, Atlanta, Georgia., Hoffman MN; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina; CSTE applied epidemiology fellow, Council of State and Territorial Epidemiologists, Atlanta, Georgia., Dandeneau D; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina; CSTE applied epidemiology fellow, Council of State and Territorial Epidemiologists, Atlanta, Georgia., Koehler K; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina., Moore Z; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina., Herndon S; Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina., Davidson K; Pulmonology & Critical Care, WakeMed Hospital, Raleigh, North Carolina., Fleischauer A; Center for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia; career epidemiology field officer, Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina.
Jazyk:	angličtina
Zdroj:	North Carolina medical journal [N C Med J] 2021 Nov-Dec; Vol. 82 (6), pp. 384-392.
DOI:	10.18043/ncm.82.6.384
Abstrakt:	BACKGROUND In August 2019, the North Carolina Division of Public Health (NCDPH) began investigating e-cigarette, or vaping, product use-associated lung injury (EVALI) cases as part of a national response. We describe clinical, epidemiologic, and laboratory findings of North Carolina EVALI patients. METHODS NCDPH requested that physicians report cases of respiratory illness or bilateral pulmonary infiltrates or opacities in patients who reported using e-cigarette, or vaping, products and had no infection or alternative plausible diagnoses. We reviewed medical records, interviewed patients, and tested vaping products for substances. RESULTS During August 13, 2019-February 18, 2020, 78 EVALI cases were reported in North Carolina. Median age of cases was 24 years (range: 13-72 years); 49 (63%) patients were male. Symptoms included cough (n = 70; 90%), shortness of breath (n = 66; 85%), and gastrointestinal symptoms (n = 63; 81%). Seventy-five patients (96%) were hospitalized, 32 (41%) required intensive care, and 12 (16%) required mechanical ventilation; none died. Among 20 patients interviewed, most reported using tetrahydrocannabinol (THC) (n = 16; 80%) or nicotine-containing products (n = 14; 70%). All obtained THC-containing products from informal sources, such as family, friends, or dealers, as THC is illegal in North Carolina. Among 82 products tested, 74 (90%) contained THC, cannabidiol, or cannabinol; 54 (66%) contained vitamin E acetate. LIMITATIONS In North Carolina, EVALI is not reportable by law, and THC is illegal. Thus, cases and exposures are likely underreported. CONCLUSIONS THC-containing products, particularly those containing vitamin E acetate, are associated with EVALI. Persons should not use these products, particularly from informal sources. Continued communication of health risks to persons who use e-cigarette, or vaping, products is essential. (©2021 by the North Carolina Institute of Medicine and The Duke Endowment. All rights reserved.)
Databáze:	MEDLINE
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