Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory.

Autor: Joseph NF; The Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research Institute, La Jolla, CA, 92037, USA.; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA., Zucca A; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA., Wingfield JL; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA., Espadas I; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA., Page D; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA., Puthanveettil SV; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, 33458, USA. sputhanv@scripps.edu.
Jazyk: angličtina
Zdroj: Molecular brain [Mol Brain] 2021 Nov 08; Vol. 14 (1), pp. 162. Date of Electronic Publication: 2021 Nov 08.
DOI: 10.1186/s13041-021-00873-9
Abstrakt: Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic cortex for their role in mediating contextual fear, a form of associative memory. KIFs function as critical mediators of synaptic transmission and plasticity by their ability to modulate microtubule function and transport of gene products. However, the regulation and function of KIFs in the prelimbic cortex insofar as mediating memory consolidation is not known. We find that within one hour of contextual fear conditioning, the expression of KIF3B is upregulated in the prelimbic but not the infralimbic cortex. Importantly, lentiviral-mediated knockdown of KIF3B in the prelimbic cortex produces deficits in consolidation while reducing freezing behavior during extinction of contextual fear. We also find that the depletion of KIF3B increases spine density within prelimbic neurons. Taken together, these results illuminate a key role for KIF3B in the prelimbic cortex as far as mediating contextual fear memory.
(© 2021. The Author(s).)
Databáze: MEDLINE
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