Verrucous venous malformation with thrombocytopenia in a neonate.

Autor: Reyes-Hadsall SC; University of Miami Miller School of Medicine, Miami, FL, USA.; Children's Skin Center, Miami, FL, USA., Fayiga FF; Children's Skin Center, Miami, FL, USA.; Division of Dermatology, Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL, USA.; The Dr. Philip Frost Department of Dermatology and Cutaneous Surgery at The University of Miami Miller School of Medicine, Miami, FL, USA., Duarte AM; Children's Skin Center, Miami, FL, USA.; Division of Dermatology, Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL, USA.; The Dr. Philip Frost Department of Dermatology and Cutaneous Surgery at The University of Miami Miller School of Medicine, Miami, FL, USA.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2021 Nov; Vol. 38 (6), pp. 1553-1557. Date of Electronic Publication: 2021 Nov 08.
DOI: 10.1111/pde.14857
Abstrakt: Verrucous venous malformations (VVM) are rare, congenital, slow-flow vascular anomalies that have been historically difficult to characterize due to clinical mimics and unclear histological evaluation. A life-threatening complication of VVMs is localized intravascular coagulation. Herein, we describe a male neonate who presented with a congenital VVM on the left lower extremity with associated severe thrombocytopenia. We discuss the multifaceted diagnostic approach used to identify this VVM, while highlighting the use of WT-1 as a negative predictive marker; we additionally outline novel treatment options and management beyond cutaneous involvement.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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