Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir.

Autor: He S; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Radeke C; Department of Health Technology, Technical University of Denmark, Building 423, 2800 Kgs. Lyngby, Denmark., Jacobsen J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Lind JU; Department of Health Technology, Technical University of Denmark, Building 423, 2800 Kgs. Lyngby, Denmark. Electronic address: joli@dtu.dk., Mu H; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: huiling.mu@sund.ku.dk.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2021 Dec 15; Vol. 610, pp. 121236. Date of Electronic Publication: 2021 Nov 05.
DOI: 10.1016/j.ijpharm.2021.121236
Abstrakt: Oromucosal patches for drug delivery allow fast onset of action and ability to circumvent hepatic first pass metabolism of drugs. While conventional fabrication methods such as solvent casting or hot melt extrusion are ideal for scalable production of low-cost delivery patches, these methods chiefly allow for simple, homogenous patch designs. As alternative, a multi-material direct-ink-write 3D printing for rapid fabrication of complex oromucosal patches with unique design features was demonstrated in the present study. Specifically, three print-materials: an acidic saquinavir-loaded hydroxypropyl methylcellulose ink, an alkaline effervescent sodium carbonate-loaded ink, and a methyl cellulose backing material were combined in various designs. The CO 2 content and pH of the microenvironment were controlled by adjusting the number of alkaline layers in the patch. Additionally, the rigid and brittle patches were converted to compliant and stretchable patches by implementing mesh-like designs. Our results illustrate how 3D printing can be used for rapid design and fabrication of multifunctional or customized oromucosal patches with tailored dosages and changed drug permeation.
(Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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