| Autor: |
Camargo A; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil., Dalmagro AP; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil.; Programa de Pós-Graduação em Química, Departamento de Química, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil., Rebelo AM; Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina - EPAGRI, Itajaí, Santa Catarina, Brazil., Reinke CK; Serviço Nacional de Aprendizagem Industrial - SENAI, Instituto SENAI de Tecnologia Ambiental, Blumenau, Santa Catarina, Brazil., Zeni ALB; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil.; Programa de Pós-Graduação em Química, Departamento de Química, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil. |
| Abstrakt: |
Considering the drawbacks elicited by the conventional antidepressants, the interest in natural products for the management of major depressive disorder has increased in the last years. Therefore, this study investigated the phenolic profile of Maclura tinctoria leaf aqueous extract (MtAE) and its possible antidepressant-like effect in mice. The LC-MS/MS analysis demonstrated MtAE has epicatechin as the major phenolic, followed by catechin, gallic acid, quercetin, syringaldehyde, ferulic acid, and syringic acid. Moreover, the acute treatment of MtAE elicited an antidepressant-like response in mice. Importantly, this antidepressant-like effect produced by MtAE was reinforced in the chronic corticosterone (20 mg/kg p.o.) administration model. MtAE treatment was also effective to protect hippocampal and cerebrocortical slices against glutamatergic excitotoxicity. Our results indicated that MtAE displayed antidepressant-like and neuroprotective effects and these responses could be associated with the presence of the phenolic compounds identified. |
