Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection.
Autor: | Lau EH; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Hui DS; Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, China., Tsang OT; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, China., Chan WH; Department of Paediatrics, Queen Elizabeth Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, China., Kwan MY; Department of Paediatric and Adolescent Medicine, Princess Margaret Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, China., Chiu SS; Department of Paediatric and Adolescent Medicine, The University of Hong Kong and Queen Mary Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, China., Cheng SM; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Ko RL; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Li JK; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Chaothai S; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Tsang CH; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Poon LL; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China.; HKU-Pasteur Research Pole, The University of Hong Kong, Special Administrative Region of Hong Kong, China., Peiris M; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, China.; HKU-Pasteur Research Pole, The University of Hong Kong, Special Administrative Region of Hong Kong, China. |
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Jazyk: | angličtina |
Zdroj: | EClinicalMedicine [EClinicalMedicine] 2021 Nov; Vol. 41, pp. 101174. Date of Electronic Publication: 2021 Oct 30. |
DOI: | 10.1016/j.eclinm.2021.101174 |
Abstrakt: | Background: The duration of immunity in SARS-CoV-2 infected people remains unclear. Neutralizing antibody responses are the best available correlate of protection against re-infection. Recent studies estimated that the correlate of 50% protection from re-infection was 20% of the mean convalescent neutralizing antibody titre. Methods: We collected sera from a cohort of 124 individuals with RT-PCR confirmed SARS-CoV-2 infections from Prince of Wales Hospital, Princess Margaret Hospital, Queen Elizabeth Hospital and Queen Mary Hospitals of the Hospital Authority of Hong Kong, for periods up to 386 days after symptom onset and tested these for antibody to SARS-CoV-2 using 50% virus plaque reduction neutralization tests (PRNT Findings: Because the rate of antibody waning slows with time, we fitted lines of decay to 115 sera from 62 patients collected beyond 90 days after symptom onset and estimate that PRNT Interpretation: The data suggest that symptomatic COVID-19 disease is followed by relatively long-lived protection from re-infection by antigenically similar viruses. Funding: Health and Medical Research Fund, Commissioned research on Novel Coronavirus Disease (COVID-19) (Reference Nos. COVID190126 and COVID1903003) from the Food and Health Bureau and the Theme-based Research Scheme project no. T11-712/19-N, the University Grants Committee of the Hong Kong SAR Government. Competing Interests: Dr. Peiris reports grants from Health & Medical Research Fund, Hong Kong (COVID190126), grants from Health & Medical Research Fund, Hong Kong (COVID1903003), grants from University Grants Committee, Hong Kong (T11–712/19-N), during the conduct of the study; Dr. Hui reports grants from Health & Medical Research Fund COVID-19 1,903,003, HKSAR government, during the conduct of the study; all the other authors reports no conflicts. (© 2021 The Author(s).) |
Databáze: | MEDLINE |
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