Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

Autor: Kong JW; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Lam Z; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Chan KH; Yale-NUS College, 16 College Avenue West, Singapore 138527, Singapore., Ganguly R; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Joey Lee JY; Agency for Science, Technology, and Research (ASTAR), Bioinformatics Institute (BII), Singapore 138671, Singapore., Loo LH; Agency for Science, Technology, and Research (ASTAR), Bioinformatics Institute (BII), Singapore 138671, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Webster RD; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Wong ZX; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Leong WK; Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2021 Oct 22; Vol. 6 (43), pp. 29045-29053. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).
DOI: 10.1021/acsomega.1c04116
Abstrakt: A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os 3 (CO) 10 (μ-H)[μ-SC 6 H 4 - p -B(OH) 2 ]} ( 2 ) could be chemically oxidized to its hydroxy analogue [Os 3 (CO) 10 (μ-H)(μ-SC 6 H 4 -p -OH)] ( 2-OH ), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.
Competing Interests: The authors declare no competing financial interest.
(© 2021 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
Externí odkaz: