Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.

Autor:	Yang Q; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA., Ciebiera M; Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, ul. Cegłowska 80, 01-809, Warsaw, Poland., Bariani MV; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA., Ali M; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt., Elkafas H; Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of Pharmacology and Toxicology, Egyptian Drug Authority, formerly National Organization for Drug Control and Research, Cairo 35521, Egypt., Boyer TG; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229-3900, USA., Al-Hendy A; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Jazyk:	angličtina
Zdroj:	Endocrine reviews [Endocr Rev] 2022 Jul 13; Vol. 43 (4), pp. 678-719.
DOI:	10.1210/endrev/bnab039
Abstrakt:	Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or noninvasive treatment option exists for hormone-dependent uterine fibroids, due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and the complexity of uterine fibroids can contribute to the progress of newer targeted therapies. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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