New Type III CRISPR variant and programmable RNA targeting tool: Oh, thank heaven for Cas7-11.
| Autor: | Catchpole RJ; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Terns MP; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA; Department of Genetics, University of Georgia, Athens, GA 30602, USA; Department of Microbiology, University of Georgia, Athens, GA 30602, USA. Electronic address: mterns@uga.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2021 Nov 04; Vol. 81 (21), pp. 4354-4356. |
| DOI: | 10.1016/j.molcel.2021.10.014 |
| Abstrakt: | Özcan et al. (2021) and van Beljouw et al. (2021) characterize a novel Type III-E CRISPR-Cas subtype, composed of a single polypeptide with crRNA processing and sequence-specific RNA cleavage activities, that provides a new RNA knockdown tool for mammalian cells with fewer off-target effects than current technologies. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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