Exciting new tools for studying TREM2 in dementia.
| Autor: | Menzies GE; Dementia Research Institute and School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AT, UK., Torvell M; Dementia Research Institute and Department of Immunology and Infection, School of Medicine, Cardiff University, CF24 4HQ, UK. Electronic address: menziesg@cardiff.ac.uk. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Structure (London, England : 1993) [Structure] 2021 Nov 04; Vol. 29 (11), pp. 1215-1216. |
| DOI: | 10.1016/j.str.2021.10.009 |
| Abstrakt: | TREM2 has long been implicated as an Alzheimer's disease (AD) risk gene. In this issue of Structure, Szykowska et al. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|