Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions.

Autor: Ong Q; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Mao T; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Iranpour Anaraki N; Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen, 9014, Switzerland.; Laboratory of Particles-Biology Interactions, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen, 9014, Switzerland.; Department of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, 1700, Switzerland., Richter Ł; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Malinverni C; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Xu X; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Olgiati F; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Silva PHJ; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Murello A; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch., Neels A; Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen, 9014, Switzerland.; Department of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg, 1700, Switzerland., Demurtas D; Interdisciplinary Centre for Electron Microscopy (CIME), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Shimizu S; York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK., Stellacci F; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. francesco.stellacci@epfl.ch.; Bioengineering Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: Materials horizons [Mater Horiz] 2022 Jan 04; Vol. 9 (1), pp. 303-311. Date of Electronic Publication: 2022 Jan 04.
DOI: 10.1039/d1mh01461g
Abstrakt: Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles (diameter < 5 nm). Tomograms are reconstructed from tilt-series 2D images. Once the three-dimensional (3D) coordinates for the centres of mass of all of the particles in the sample are determined, we calculate the pair distribution function g ( r ) and the potential of mean force U ( r ) without any assumption. Importantly, we show that further quantitative information from 3D tomograms is readily available as the spatial fluctuation in the particles' position can be efficiently determined. This in turn allows for the prompt derivation of the Kirkwood-Buff integrals with all their associated quantities such as the second virial coefficient. Finally, the structure factor and the agglomeration states of the particles are evaluated directly. These thermodynamic quantities provide key insights into the dispersion properties of the particles. The method works well both for dispersed systems containing isolated particles and for systems with varying degrees of agglomerations.
Databáze: MEDLINE
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