High-resolution intravascular magnetic resonance imaging of the coronary artery wall at 3.0 Tesla: toward evaluation of atherosclerotic plaque vulnerability.

Autor:	Meng Y; Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Mo Z; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; The Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China., Hao J; Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Peng Y; Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Yan H; Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Mu J; Department of Cardiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Ma D; Department of Cardiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China., Zhang X; Department of Biomedical Engineering, State University of New York at Buffalo, NY, USA., Li Y; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; The Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China.
Jazyk:	angličtina
Zdroj:	Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2021 Nov; Vol. 11 (11), pp. 4522-4529.
DOI:	10.21037/qims-21-286
Abstrakt:	Background: To validate the feasibility of generating high-resolution intravascular 3.0 Tesla (T) magnetic resonance imaging of the coronary artery wall to further plaque imaging. Methods: A receive-only 0.014-inch diameter magnetic resonance imaging guidewire (MRIG) was manufactured for intravascular imaging within a phantom experiment and the coronary artery wall of the swine. For coronary artery wall imaging, both high-resolution images and conventional resolution images were acquired. A 16-channel commercial surface coil for magnetic resonance imaging was employed for the control group. Results: For the phantom experiment, the MRIG showed a higher signal-to-noise ratio than the surface coil. The peak signal-to-noise ratio of the MRIG and the surface coil-generated imaging were 213.6 and 19.8, respectively. The signal-to-noise ratio decreased rapidly as the distance from the MRIG increased. For the coronary artery wall experiment, the vessel wall imaging by the MRIG could be identified clearly, whereas the vessel wall imaging by the surface coil was blurred. The average signal-to-noise ratio of the artery wall was 21.1±5.40 by the MRIG compared to 8.4±2.19 by the surface coil, where the resolution was set at 0.2 mm × 0.2 mm × 2 mm. As expected, the high-resolution sequence clearly showed more details than the conventional resolution sequence set at 0.7 mm × 0.7 mm × 2.0 mm. Histological examination showed no evidence of mechanical injuries in the target vessel walls. Conclusions: The study validated the feasibility of generating magnetic resonance imaging (MRI) at 0.2 mm × 0.2 mm × 2 mm for the coronary artery wall using a 0.014 inch MRIG. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/qims-21-286). Dr. XZ serves as an Associate Editor of Quantitative Imaging in Medicine and Surgery. Dr. YM reports that his institution is funded by the National Natural Science Foundation of China (Grant No.: 81671789) and the Project of Health Commission of Shanxi Province (No.: 2018109). Dr. YL reports that his institution is funded by the National Key R&D Program of China 2021YFE0204400; the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB25000000); city grant RCYX20200714114735123; Guangdong Province grant 2020B1212060051; and Youth Innovation Promotion Association of CAS No. 2017415. The other authors have no conflicts of interest to declare. (2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.)
Databáze:	MEDLINE
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