Effectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study.

Autor:	Raeissadat SA; Physiatrist, Associate Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rayegani SM; Physiatrist, Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Sohrabi MR; Community Medicine Specialist, Professor, Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jafarian N; Physiatry Resident, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Bahrami MN; Orthopedic Surgeon, Pediatric Orthopedics Fellowship, Orthopedic Surgery Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2021 Oct 11; Vol. 7 (9), pp. FSO759. Date of Electronic Publication: 2021 Oct 11 (Print Publication: 2021).
DOI:	10.2144/fsoa-2021-0069
Abstrakt:	Aim: Knee osteoarthritis is a common disabling disorder, with no curative treatment. This study aims to assess autologous conditioned serum effectiveness in its treatment. Materials & Methods: Following a systematic search (2000-2020) on major databases and screening and filtering processes, eight articles were included in the final analyses. The pooled effect of visual analog scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) variables was evaluated before and after the intervention. Results: The combined standardized mean difference for the global WOMAC score was -2.44 and the combined weighted mean difference was -22.92. The combined standardized mean difference for the VAS score was -3.77 and the combined weighted mean difference was -32.37 (p < 0.000). Conclusion: This meta-analysis reported that the autologous conditioned serum can reduce pain and improve function (VAS and WOMAC outcome measures) in patients with knee osteoarthritis. Competing Interests: Financial & competing interests disclosure This study was funded (in terms of affording the expenses for data entry and analysis) by the Physical Medicine and Rehabilitation Research Center, Shohada-e Tajrish hospital, School of Medicine, Shahid Beheshti Medical University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. (© 2021 Seyed Ahmad Raeissadat.)
Databáze:	MEDLINE
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