Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.
Autor: | Hawkins NC; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., Kizziah JL; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., Penadés JR; Center for Molecular Bacteriology and Infection, Imperial College London, London, UK., Dokland T; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. dokland@uab.edu. |
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Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2021 Nov 04; Vol. 12 (1), pp. 6408. Date of Electronic Publication: 2021 Nov 04. |
DOI: | 10.1038/s41467-021-26759-x |
Abstrakt: | Staphylococcus aureus pathogenicity islands (SaPIs) are molecular parasites that hijack helper phages for their transfer. SaPIbov5, the prototypical member of a family of cos type SaPIs, redirects the assembly of ϕ12 helper capsids from prolate to isometric. This size and shape shift is dependent on the SaPIbov5-encoded protein Ccm, a homolog of the ϕ12 capsid protein (CP). Using cryo-electron microscopy, we have determined structures of prolate ϕ12 procapsids and isometric SaPIbov5 procapsids. ϕ12 procapsids have icosahedral end caps with T (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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