Drosophila ß Heavy -Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil.
Autor: | Pogodalla N; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany., Kranenburg H; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany., Rey S; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany., Rodrigues S; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany., Cardona A; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, CB2 OQH, UK.; Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, UK.; HHMI Janelia Research Campus, Ashburn, VA, USA., Klämbt C; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany. klaembt@uni-muenster.de. |
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Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2021 Nov 04; Vol. 12 (1), pp. 6357. Date of Electronic Publication: 2021 Nov 04. |
DOI: | 10.1038/s41467-021-26462-x |
Abstrakt: | In the central nervous system (CNS), functional tasks are often allocated to distinct compartments. This is also evident in the Drosophila CNS where synapses and dendrites are clustered in distinct neuropil regions. The neuropil is separated from neuronal cell bodies by ensheathing glia, which as we show using dye injection experiments, contribute to the formation of an internal diffusion barrier. We find that ensheathing glia are polarized with a basolateral plasma membrane rich in phosphatidylinositol-(3,4,5)-triphosphate (PIP (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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